Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue

The assessment of proarrhythmic risks of drugs remains challenging. To evaluate the suitability of rat engineered heart tissue (EHT) for detecting proarrhythmic effects. We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode)...

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Bibliografiska uppgifter
Huvudupphovsmän: Eder, Alexandra, Hansen, Arne, Uebeler, June, Schulze, Thomas, Neuber, Christiane, Schaaf, Sebastian, Yuan, Lei, Christ, Torsten, Vos, Marc A., Eschenhagen, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2014
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Original Contribution
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160570/
https://ncbi.nlm.nih.gov/pubmed/25209140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-014-0436-7
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