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Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue

The assessment of proarrhythmic risks of drugs remains challenging. To evaluate the suitability of rat engineered heart tissue (EHT) for detecting proarrhythmic effects. We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode)...

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Detalhes bibliográficos
Main Authors: Eder, Alexandra, Hansen, Arne, Uebeler, June, Schulze, Thomas, Neuber, Christiane, Schaaf, Sebastian, Yuan, Lei, Christ, Torsten, Vos, Marc A., Eschenhagen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160570/
https://ncbi.nlm.nih.gov/pubmed/25209140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-014-0436-7
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