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Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma

ZBP-89 regulates Bak to facilitate apoptosis in cancer cells. This study examined if ZBP-89 regulates Bak through an epigenetic mechanism in hepatocellular carcinoma (HCC). We first demonstrated that the expression of Bak was reduced but the levels of DNMT1 and HDAC3 were increased in HCC cancer tis...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ye, Cai Guo, Chen, George G, Ho, Rocky LK, Merchant, Juanita L, He, Ming-Liang, Lai, Paul BS
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160027/
https://ncbi.nlm.nih.gov/pubmed/23954442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.08.001
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