A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.

The application of DNA technology to regulate the transcription of disease-related genes in vivo has important therapeutic potentials. The transcription factor E2F plays a pivotal role in the coordinated transactivation of cell cycle-regulatory genes such as c-myc, cdc2, and the gene encoding prolif...

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Hlavní autoři: Morishita, R, Gibbons, G H, Horiuchi, M, Ellison, K E, Nakama, M, Zhang, L, Kaneda, Y, Ogihara, T, Dzau, V J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC41600/
https://ncbi.nlm.nih.gov/pubmed/7597041
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