Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction

We previously demonstrated that mice which overexpress human renin and angiotensinogen (R+A+) show enhanced cerebral damage in both in vivo and in vitro experimental ischemia models. Angiotensin converting enzyme 2 (ACE2) counteracts the effects of angiotensin (Ang-II) by transforming it into Ang-(1...

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Detalhes bibliográficos
Main Authors: Zheng, Jiaolin, Li, Guangze, Chen, Shuzhen, Chen, Ji, Buck, Joshua, Zhu, Yulan, Xia, Huijing, Lazartigues, Eric, Chen, Yanfang, Olson, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159741/
https://ncbi.nlm.nih.gov/pubmed/24814023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2014.04.060
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