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Clinical Utility and Analytical Challenges in Measurement of Cerebrospinal Fluid Amyloid-β(1–42) and τ Proteins as Alzheimer Disease Biomarkers

BACKGROUND: Over the past 2 decades, clinical studies have provided evidence that cerebrospinal fluid (CSF) amyloid β(1–42) (Aβ(1–42)), total τ(t-τ), and τ phosphorylated at Thr181 (p-τ(181)) are reliable biochemical markers of Alzheimer disease (AD) neuropathology. CONTENT: In this review, we summa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kang, Ju-Hee, Korecka, Magdalena, Toledo, Jon B., Trojanowski, John Q., Shaw, Leslie M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159709/
https://ncbi.nlm.nih.gov/pubmed/23519967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2013.202937
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