PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis

Metastatic dissemination is often initiated by the reactivation of an embryonic development program referred to as epithelial-mesenchymal transition (EMT). The transcription factor SNAIL promotes EMT and elicits associated pathological characteristics, such as invasion, metastasis and stemness. To b...

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Autori principali: Zheng, Hanqiu, Shen, Minhong, Cha, Yin-Lian, Li, Wenyang, Wei, Yong, Blanco, Mario Andres, Ren, Guangwen, Zhou, Tianhua, Storz, Peter, Wang, Hui-Yun, Kang, Yibin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159622/
https://ncbi.nlm.nih.gov/pubmed/25203322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.07.022
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