Decreased Frequencies of Circulating Follicular Helper T Cell Counterparts and Plasmablasts in Ankylosing Spondylitis Patients Naïve for TNF Blockers

Follicular helper T cells (Tfh), localized in lymphoid organs, promote B cell differentiation and function. Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of Tfh. Three subpopulations of circulating CD4+CXCR5+ cells have been described: CXCR3+CCR6- (Tfh-Th1), CXCR3-CCR6+...

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Main Authors: Bautista-Caro, María-Belén, Arroyo-Villa, Irene, Castillo-Gallego, Concepción, de Miguel, Eugenio, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, Villalba, Alejandro, Sánchez-Mateos, Paloma, Puig-Kröger, Amaya, Martín-Mola, Emilio, Miranda-Carús, María-Eugenia
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159293/
https://ncbi.nlm.nih.gov/pubmed/25203742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107086
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