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Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition
[Image: see text] With current therapies becoming less efficacious due to increased drug resistance, new inhibitors of both bacterial and malarial targets are desperately needed. The recently discovered methylerythritol phosphate (MEP) pathway for isoprenoid synthesis provides novel targets for the...
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| Asıl Yazarlar: | , , , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American
Chemical Society
2014
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4159220/ https://ncbi.nlm.nih.gov/pubmed/25221444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct5005214 |
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