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Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition

[Image: see text] With current therapies becoming less efficacious due to increased drug resistance, new inhibitors of both bacterial and malarial targets are desperately needed. The recently discovered methylerythritol phosphate (MEP) pathway for isoprenoid synthesis provides novel targets for the...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Blachly, Patrick G., Sandala, Gregory M., Giammona, Debra Ann, Liu, Tiqing, Bashford, Donald, McCammon, J. Andrew, Noodleman, Louis
التنسيق: Artigo
اللغة:Inglês
منشور في: American Chemical Society 2014
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159220/
https://ncbi.nlm.nih.gov/pubmed/25221444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct5005214
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