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Selective enrichment of damaged DNA molecules for ancient genome sequencing

Contamination by present-day human and microbial DNA is one of the major hindrances for large-scale genomic studies using ancient biological material. We describe a new molecular method, U selection, which exploits one of the most distinctive features of ancient DNA—the presence of deoxyuracils—for...

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Detalhes bibliográficos
Main Authors: Gansauge, Marie-Theres, Meyer, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158764/
https://ncbi.nlm.nih.gov/pubmed/25081630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.174201.114
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