Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock

OBJECTIVES: We have previously demonstrated that a stable synthetic analog of 20-hydroxyeicosatetraenoic acid (20-HETE), N-(20-hydroxyeicosa-5[Z],14[Z]-dienoyl)glycine (5,14-HEDGE), which mimics the effects of endogenously produced 20-HETE, prevents vascular hyporeactivity, hypotension, tachycardia,...

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Bibliografiset tiedot
Päätekijät: Sari, A. Nihal, Korkmaz, Belma, Serin, Mehmet Sami, Kacan, Meltem, Unsal, Demet, Buharalioglu, C. Kemal, Firat, Seyhan Sahan, Manhati, Vijay L., Falck, John R., Malik, Kafait U., Tunctan, Bahar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158117/
https://ncbi.nlm.nih.gov/pubmed/24915805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00011-014-0747-z
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