Human Immunodeficiency Virus Type 1 (HIV-1) Integrase: Resistance to Diketo Acid Integrase Inhibitors Impairs HIV-1 Replication and Integration and Confers Cross-Resistance to l-Chicoric Acid

The diketo acids are potent inhibitors of human immunodeficiency virus (HIV) integrase (IN). Mutations in IN, T66I, S153Y, and M154I, as well as T66I-S153Y and T66I-M154I double mutations, confer resistance to diketo acids (D. J. Hazuda et al., Science 287:646-650, 2000). The effects of these IN mut...

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Bibliographic Details
Main Authors: Lee, Deborah J., Robinson, W. E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC415810/
https://ncbi.nlm.nih.gov/pubmed/15140981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.5835-5847.2004
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