Mobilization of healthy donors with plerixafor affects the cellular composition of T-cell receptor (TCR)-αβ/CD19-depleted haploidentical stem cell grafts

BACKGROUND: HLA-haploidentical hematopoietic stem cell transplantation (HSCT) is suitable for patients lacking related or unrelated HLA-matched donors. Herein, we investigated whether plerixafor (MZ), as an adjunct to G-CSF, facilitated the collection of mega-doses of hematopoietic stem cells (HSC)...

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Hauptverfasser: Rutella, Sergio, Filippini, Perla, Bertaina, Valentina, Li Pira, Giuseppina, Altomare, Lidia, Ceccarelli, Stefano, Brescia, Letizia P, Lucarelli, Barbarella, Girolami, Elia, Conflitti, Gianpiero, Cefalo, Maria Giuseppina, Bertaina, Alice, Corsetti, Tiziana, Moretta, Lorenzo, Locatelli, Franco
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158047/
https://ncbi.nlm.nih.gov/pubmed/25179788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0240-z
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