On the perils of poor editing: Regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes

This review discusses mechanisms that link allelic variants of MHC class II molecules (MHCII) to immune pathology. We focus on HLA-DQ (DQ) alleles associated with celiac disease (CD) and type 1 diabetes (T1D) and the role of the murine DQ-like allele, H2-A(g7) (A(g7)), in murine T1D. MHCII molecules...

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Hlavní autoři: Busch, Robert, De Riva, Alessandra, Hadjinicolaou, Andreas V., Jiang, Wei, Hou, Tieying, Mellins, Elizabeth D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157902/
https://ncbi.nlm.nih.gov/pubmed/22805744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/erm.2012.9
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