Ikaros and RAG-2-Mediated Antisense Transcription Are Responsible for Lymphocyte-Specific Inactivation of NWC Promoter

Recombination activating gene-2 (RAG-2) and NWC are strongly evolutionarily conserved overlapping genes which are convergently transcribed. In non-lymphoid cells the NWC promoter is active whereas in lymphocytes it is inactive due to the DNA methylation. Analysing the mechanism responsible for lymph...

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Detalhes bibliográficos
Main Authors: Łaszkiewicz, Agnieszka, Bzdzion, Łukasz, Kasztura, Monika, Śnieżewski, Łukasz, Janik, Sylwia, Kisielow, Paweł, Cebrat, Małgorzata
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157847/
https://ncbi.nlm.nih.gov/pubmed/25198102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106927
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