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NBD-labelled phospholipid accelerates apolipoprotein C-II amyloid fibril formation but is not incorporated into mature fibrils

Human apolipoprotein (apo) C-II is one of several lipid-binding proteins that self-assemble into fibrils and accumulate in disease-related amyloid deposits. A general characteristic of these amyloid deposits is the presence of lipids, known to modulate individual steps in amyloid fibril formation. A...

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Main Authors: Ryan, Timothy M., Griffin, Michael D. W., Bailey, Michael F., Schuck, Peter, Howlett, Geoffrey J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157729/
https://ncbi.nlm.nih.gov/pubmed/21985034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201192r
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