Host-derived CD4(+) T cells attenuate stem cell mediated transfer of autoimmune arthritis in lethally irradiated B6.g7 mice

OBJECTIVE: In the KBxN mouse model of inflammatory arthritis, T cells carrying a transgenic TCR initiate disease by helping B cells to produce arthritogenic anti-GPI (glucose -6-phosphate isomerase) autoantibodies. We found that lethally-irradiated lymphocyte-deficient B6.g7 (I-A(g7+)) Rag(-/-) mice...

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Main Authors: Rajasekaran, Narendiran, Wang, Nan, Truong, Phi, Rinderknecht, Cornelia, Macaubas, Claudia, Beilhack, Georg F, Shizuru, Judith A., Mellins, Elizabeth D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157728/
https://ncbi.nlm.nih.gov/pubmed/23233229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37800
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