B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes

In BDC2·5 non-obese diabetic (BDC2·5NOD) mice, a spontaneous model of type 1 diabetes, CD4(+) T cells express a transgene-encoded T cell receptor (TCR) with reactivity against a pancreatic antigen, chromogranin. This leads to massive infiltration and destruction of the pancreatic islets and subseque...

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Detalhes bibliográficos
Main Authors: Rajasekaran, N, Wang, N, Hang, Y, Macaubas, C, Rinderknecht, C, Beilhack, G F, Shizuru, J A, Mellins, E D
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784210/
https://ncbi.nlm.nih.gov/pubmed/23795893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12163
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