Two Oligopeptide-Permease-Encoding Genes in the Clavulanic Acid Cluster of Streptomyces clavuligerus Are Essential for Production of the β-Lactamase Inhibitor

orf7 (oppA1) and orf15 (oppA2) are located 8 kb apart in the clavulanic acid gene cluster of Streptomyces clavuligerus and encode proteins which are 48.0% identical. These proteins show sequence similarity to periplasmic oligopeptide-binding proteins. Mutant S. clavuligerus oppA1::acc, disrupted in...

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Bibliographische Detailangaben
Hauptverfasser: Lorenzana, Luis M., Pérez-Redondo, Rosario, Santamarta, Irene, Martín, Juan F., Liras, Paloma
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Genetics and Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC415745/
https://ncbi.nlm.nih.gov/pubmed/15150229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.11.3431-3438.2004
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