Live SIV vaccine correlate of protection: local antibody production and concentration on the path of virus entry

We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymp...

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Hlavní autoři: Li, Qingsheng, Zeng, Ming, Duan, Lijie, Voss, James E., Smith, Anthony J., Pambuccian, Stefan, Shang, Liang, Wietgrefe, Stephen, Southern, Peter J., Reilly, Cavan S., Skinner, Pamela J., Zupancic, Mary L., Carlis, John V., Piatak, Michael, Waterman, Diane, Reeves, R. Keith, Masek-Hammerman, Katherine, Derdeyn, Cynthia A., Alpert, Michael D., Evans, David T., Kohler, Heinz, Muller, Sybille, Robinson, James, Lifson, Jeffrey D., Burton, Dennis R., Johnson, R. Paul, Haase, Ashley T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157131/
https://ncbi.nlm.nih.gov/pubmed/25135832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400820
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