Live SIV vaccine correlate of protection: local antibody production and concentration on the path of virus entry

We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymp...

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Bibliografiske detaljer
Main Authors: Li, Qingsheng, Zeng, Ming, Duan, Lijie, Voss, James E., Smith, Anthony J., Pambuccian, Stefan, Shang, Liang, Wietgrefe, Stephen, Southern, Peter J., Reilly, Cavan S., Skinner, Pamela J., Zupancic, Mary L., Carlis, John V., Piatak, Michael, Waterman, Diane, Reeves, R. Keith, Masek-Hammerman, Katherine, Derdeyn, Cynthia A., Alpert, Michael D., Evans, David T., Kohler, Heinz, Muller, Sybille, Robinson, James, Lifson, Jeffrey D., Burton, Dennis R., Johnson, R. Paul, Haase, Ashley T.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157131/
https://ncbi.nlm.nih.gov/pubmed/25135832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400820
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