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Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

The hallmark of HIV-1 and SIV infections is CD4(+) T cell depletion. Both direct cell killing and indirect mechanisms related to immune activation have been suggested to cause the depletion of T cells. We have now identified a mechanism by which immune activation-induced fibrosis of lymphoid tissues...

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Detalhes bibliográficos
Main Authors: Zeng, Ming, Smith, Anthony J., Wietgrefe, Stephen W., Southern, Peter J., Schacker, Timothy W., Reilly, Cavan S., Estes, Jacob D., Burton, Gregory F., Silvestri, Guido, Lifson, Jeffrey D., Carlis, John V., Haase, Ashley T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049394/
https://ncbi.nlm.nih.gov/pubmed/21393864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45157
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