A NOVEL ROLE FOR HISTONE DEACETYLASE 6 (HDAC6) IN THE REGULATION OF THE TOLEROGENIC STAT3/IL-10 PATHWAY IN ANTIGEN PRESENTING CELLS

Antigen-presenting cells (APCs) are critical in T-cell activation and in the induction of T-cell tolerance. Epigenetic modifications of specific genes in the APC play a key role in this process, and among them, histone deacetylases (HDACs) have emerged as key participants. HDAC6, one of the members...

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Autori principali: Cheng, Fengdong, Lienlaf, Maritza, Wang, Hong-Wei, Perez-Villarroel, Patricio, Lee, Calvin, Woan, Karrune, Rock-Klotz, Jennifer, Sahakian, Eva, Woods, David, Pinilla-Ibarz, Javier, Kalin, Jay, Tao, Jianguo, Hancock, Wayne, Kozikowski, Alan, Seto, Edward, Villagra, Alejandro, Sotomayor, Eduardo M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157123/
https://ncbi.nlm.nih.gov/pubmed/25108026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302778
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