A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function

NKG2D is a stimulatory receptor expressed by NK cells and a subset of T cells. NKG2D is crucial in diverse aspects of innate and adaptive immune functions. Here, we characterize a novel splice variant of human NKG2D that encodes a truncated receptor lacking the ligand-binding ectodomain. This trunca...

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Detaylı Bibliyografya
Asıl Yazarlar: Karimi, Mobin A., Aguilar, Oscar, Zou, Baixiang, Bachmann, Michael H., Carlyle, James R., Baldwin, Cynthia L., Kambayashi, Taku
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157112/
https://ncbi.nlm.nih.gov/pubmed/25092887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400920
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