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Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation
CRISPR drives prokaryotic adaptation to invasive nucleic acids such as phages and plasmids using an RNA-mediated interference mechanism. Interference in Type I CRISPR-Cas systems requires a targeting Cascade complex and a degradation machine Cas3, which contains both nuclease and helicase activities...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156918/ https://ncbi.nlm.nih.gov/pubmed/25132177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2875 |
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