The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly

Cytoplasmic pattern recognition receptors detect non-self RNAs during virus infections and initiate antiviral signaling. One receptor, MDA5, possesses essential signaling domains, but weak RNA binding. A second receptor, LGP2, rapidly detects diverse dsRNA species, but lacks signaling domains. Accum...

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Main Authors: Bruns, Annie M., Leser, George P., Lamb, Robert A., Horvath, Curt M.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156907/
https://ncbi.nlm.nih.gov/pubmed/25127512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.07.003
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