Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis

Conflicting results have been reported for the roles of cGMP and cGMP-dependent protein kinase I (cGKI) in various pathological conditions leading to cardiac hypertrophy and fibrosis. A cardioprotective effect of cGMP/cGKI has been reported in whole animals and isolated cardiomyocytes, but recent ev...

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Bibliographic Details
Main Authors: Patrucco, Enrico, Domes, Katrin, Sbroggió, Mauro, Blaich, Anne, Schlossmann, Jens, Desch, Matthias, Rybalkin, Sergei D., Beavo, Joseph A., Lukowski, Robert, Hofmann, Franz
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156763/
https://ncbi.nlm.nih.gov/pubmed/25139994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414364111
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