The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer

Nitrogen-containing heterocyclic compounds are an important class of molecules that are commonly used for the synthesis of candidate drugs. Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) is a lipid kinase, similar to PI3K. However, the role of PIP5K1α in oncogenic processes and the development...

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Bibliografske podrobnosti
Main Authors: Semenas, Julius, Hedblom, Andreas, Miftakhova, Regina R., Sarwar, Martuza, Larsson, Rikard, Shcherbina, Liliya, Johansson, Martin E., Härkönen, Pirkko, Sterner, Olov, Persson, Jenny L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156761/
https://ncbi.nlm.nih.gov/pubmed/25071204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405801111
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