Epac, Rap and Rab3 act in concert to mobilize calcium from sperm’s acrosome during exocytosis

BACKGROUND: Exocytosis of sperm’s single secretory granule or acrosome (acrosome reaction, AR) is a highly regulated event essential for fertilization. The AR begins with an influx of calcium from the extracellular milieu and continues with the synthesis of cAMP and the activation of its target Epac...

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Bibliographic Details
Main Authors: Ruete, María C, Lucchesi, Ornella, Bustos, Matías A, Tomes, Claudia N
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156617/
https://ncbi.nlm.nih.gov/pubmed/25159528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0043-0
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