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DOSE-FINDING WITH DRUG COMBINATIONS IN CANCER PHASE I CLINICAL TRIALS USING CONDITIONAL ESCALATION WITH OVERDOSE CONTROL (EWOC)
We present a Bayesian adaptive design for dose finding of a combination of two drugs in cancer phase I clinical trials. The goal is to estimate the maximum tolerated dose (MTD) as a curve in the two-dimensional Cartesian plane. We use a logistic model to describe the relationship between the doses o...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156522/ https://ncbi.nlm.nih.gov/pubmed/24825779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6201 |
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