Frequent Discordance between ERG Gene Rearrangement and ERG Protein Expression in a Rapid Autopsy Cohort of Patients with Lethal, Metastatic, Castration-Resistant Prostate Cancer

BACKGROUND: ERG rearrangements in localized prostate cancer can be detected with high sensitivity and specificity by immunohistochemistry (IHC). However, recent data suggests that ERG IHC may be less sensitive for ERG rearrangements in castration-resistant prostate cancer (CRPC). Thus, we sought to...

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Hauptverfasser: Udager, Aaron M., Shi, Yang, Tomlins, Scott A., Alva, Ajjai, Siddiqui, Javed, Cao, Xuhong, Pienta, Kenneth J., Jiang, Hui, Chinnaiyan, Arul M., Mehra, Rohit
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156519/
https://ncbi.nlm.nih.gov/pubmed/25043157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22836
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