The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain

T-cell intracellular antigen-1 (TIA-1) is a key DNA/RNA binding protein that regulates translation by sequestering target mRNAs in stress granules (SG) in response to stress conditions. TIA-1 possesses three RNA recognition motifs (RRM) along with a glutamine-rich domain, with the central domains (R...

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Detalles Bibliográficos
Main Authors: Cruz-Gallardo, Isabel, Aroca, Ángeles, Gunzburg, Menachem J, Sivakumaran, Andrew, Yoon, Je-Hyun, Angulo, Jesús, Persson, Cecilia, Gorospe, Myriam, Karlsson, B Göran, Wilce, Jacqueline A, Díaz-Moreno, Irene
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2014
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156507/
https://ncbi.nlm.nih.gov/pubmed/24824036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.28801
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