Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen presentation by a mechanism that remains unclear and controversial. Here, we investigated the sequence and structural determinants of HLA-DM interaction. Peptides interacting nonoptimally in the P1 pocket exhibited l...

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Bibliographische Detailangaben
Hauptverfasser: Yin, Liusong, Trenh, Peter, Guce, Abigail, Wieczorek, Marek, Lange, Sascha, Sticht, Jana, Jiang, Wei, Bylsma, Marissa, Mellins, Elizabeth D., Freund, Christian, Stern, Lawrence J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156084/
https://ncbi.nlm.nih.gov/pubmed/25002586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585539
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