Interferon γ-inducible Protein (IFI) 16 Transcriptionally Regulates Type I Interferons and Other Interferon-stimulated Genes and Controls the Interferon Response to both DNA and RNA Viruses

The interferon γ-inducible protein 16 (IFI16) has recently been linked to the detection of nuclear and cytosolic DNA during infection with herpes simplex virus-1 and HIV. IFI16 binds dsDNA via HIN200 domains and activates stimulator of interferon genes (STING), leading to TANK (TRAF family member-as...

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Detalhes bibliográficos
Main Authors: Thompson, Mikayla R., Sharma, Shruti, Atianand, Maninjay, Jensen, Søren B., Carpenter, Susan, Knipe, David M., Fitzgerald, Katherine A., Kurt-Jones, Evelyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156042/
https://ncbi.nlm.nih.gov/pubmed/25002588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554147
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