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Requirements for Pseudosubstrate Arginine Residues during Autoinhibition and Phosphatidylinositol 3,4,5-(PO(4))(3)-dependent Activation of Atypical PKC
Atypical PKC (aPKC) isoforms are activated by the phosphatidylinositol 3-kinase product phosphatidylinositol 3,4,5-(PO(4))(3) (PIP(3)). How PIP(3) activates aPKC is unknown. Although Akt activation involves PIP(3) binding to basic residues in the Akt pleckstrin homology domain, aPKCs lack this domai...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4155669/ https://ncbi.nlm.nih.gov/pubmed/25035426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565671 |
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