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Class I and IIa Histone Deacetylases Have Opposite Effects on Sclerostin Gene Regulation
Adult bone mass is controlled by the bone formation repressor sclerostin (SOST). Previously, we have shown that intermittent parathyroid hormone (PTH) bone anabolic therapy involves SOST expression reduction by inhibiting myocyte enhancer factor 2 (MEF2), which activates a distant bone enhancer. Her...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4155667/ https://ncbi.nlm.nih.gov/pubmed/25012661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564997 |
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