A Novel Functional Site in the PB2 Subunit of Influenza A Virus Essential for Acetyl-CoA Interaction, RNA Polymerase Activity, and Viral Replication

The PA, PB1, and PB2 subunits, components of the RNA-dependent RNA polymerase of influenza A virus, are essential for viral transcription and replication. The PB2 subunit binds to the host RNA cap (7-methylguanosine triphosphate (m(7)GTP)) and supports the endonuclease activity of PA to “snatch” the...

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Detalhes bibliográficos
Main Authors: Hatakeyama, Dai, Shoji, Masaki, Yamayoshi, Seiya, Hirota, Takenori, Nagae, Monami, Yanagisawa, Shin, Nakano, Masahiro, Ohmi, Naho, Noda, Takeshi, Kawaoka, Yoshihiro, Kuzuhara, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155666/
https://ncbi.nlm.nih.gov/pubmed/25063805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559708
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