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Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes
AIM: Simvastatin is frequently administered to diabetic patients with hypercholesterolemia. The aim of the study was to investigate the pharmacokinetics of simvastatin and its hydrolysate simvastatin acid in a rat model of type 2 diabetes. METHODS: Diabetes was induced in 4-week-old rats by a treatm...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4155525/ https://ncbi.nlm.nih.gov/pubmed/25152023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.39 |
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