Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency

XRCC4-like factor (XLF/Cernunnos) is a component of the nonhomologous end-joining (NHEJ) pathway of double-strand DNA break repair. XLF-deficient patients develop a severe progressive lymphocytopenia. Although NHEJ is required for V(D)J recombination and lymphocyte development, XLF-deficient mice ha...

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Autors principals: Avagyan, Serine, Churchill, Michael, Yamamoto, Kenta, Crowe, Jennifer L., Li, Chen, Lee, Brian J., Zheng, Tian, Mukherjee, Siddhartha, Zha, Shan
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155271/
https://ncbi.nlm.nih.gov/pubmed/25075129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-574863
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