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MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing

Summary Molecular inversion probes (MIPs) enable cost-effective multiplex targeted gene resequencing in large cohorts. However, the design of individual MIPs is a critical parameter governing the performance of this technology with respect to capture uniformity and specificity. MIPgen is a user-frie...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Boyle, Evan A., O’Roak, Brian J., Martin, Beth K., Kumar, Akash, Shendure, Jay
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155255/
https://ncbi.nlm.nih.gov/pubmed/24867941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu353
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