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A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

A system for tetracycline-regulated inducible gene expression was described recently which relies on constitutive expression of a tetracycline-controlled transactivator (tTA) fusion protein combining the tetracycline repressor and the transcriptional activation domain of VP16 [Gossen, M. & Bujard, H...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Principais autores: Shockett, P, Difilippantonio, M, Hellman, N, Schatz, D G
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1995
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41550/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7604026/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6522
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