Known and Novel Sources of Variability in the Nicotine Metabolite Ratio in a Large Sample of Treatment-Seeking Smokers

BACKGROUND: The ratio of 3′hydroxycotinine to cotinine, or nicotine metabolite ratio (NMR), is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine metabolism, and nicotine clearance. Higher NMR (faster nicotine clearance) is associated retrospectively with heavier smoking...

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Hauptverfasser: Chenoweth, Meghan J., Novalen, Maria, Hawk, Larry W., Schnoll, Robert A., George, Tony P., Cinciripini, Paul M., Lerman, Caryn, Tyndale, Rachel F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154993/
https://ncbi.nlm.nih.gov/pubmed/25012994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-14-0427
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