Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC

Somatic mutations in Fibroblast Growth Factor Receptor 2 (FGFR2) are present in 4-5% of patients diagnosed with non-small cell lung cancer (NSCLC). Amplification and mutations in FGFR genes have been identified in patients with NSCLC and clinical trials are testing the efficacy of anti-FGFR therapie...

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Main Authors: Tchaicha, Jeremy H., Akbay, Esra A., Altabef, Abigail, Mikse, Oliver R., Kikuchi, Eiki, Rhee, Kevin, Liao, Rachel G., Bronson, Roderick T., Sholl, Lynette M., Meyerson, Matthew, Hammerman, Peter S., Wong, Kwok-Kin
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154986/
https://ncbi.nlm.nih.gov/pubmed/25035393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3218
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