Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain

Clinical genetic studies have shown that loss of Nav1.7 function leads to the complete loss of acute pain perception. The global deletion is reported lethal in mice, however, and studies of mice with promoter-specific deletions of Nav1.7 have suggested that the role of Nav1.7 in pain transduction de...

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Detalhes bibliográficos
Main Authors: Gingras, Jacinthe, Smith, Sarah, Matson, David J., Johnson, Danielle, Nye, Kim, Couture, Lauren, Feric, Elma, Yin, Ruoyuan, Moyer, Bryan D., Peterson, Matthew L., Rottman, James B., Beiler, Rudolph J., Malmberg, Annika B., McDonough, Stefan I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154897/
https://ncbi.nlm.nih.gov/pubmed/25188265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105895
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