Brain Intraventricular Injection of Amyloid-β in Zebrafish Embryo Impairs Cognition and Increases Tau Phosphorylation, Effects Reversed by Lithium

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no effective treatment and commonly diagnosed only on late stages. Amyloid-β (Aβ) accumulation and exacerbated tau phosphorylation are molecular hallmarks of AD implicated in cognitive deficits and synaptic and neuronal loss....

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Autori principali: Nery, Laura Roesler, Eltz, Natalia Silva, Hackman, Cristiana, Fonseca, Raphaela, Altenhofen, Stefani, Guerra, Heydi Noriega, Freitas, Vanessa Morais, Bonan, Carla Denise, Vianna, Monica Ryff Moreira Roca
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154875/
https://ncbi.nlm.nih.gov/pubmed/25187954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105862
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