LIN28A Expression Reduces Sickling of Cultured Human Erythrocytes

Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with sickle cell disease (SCD) and the beta-thalassemias. It was recently reported that increased expression of LIN28 proteins or decreased expression of its target let-7 miRNAs enhances HbF levels in cultured primary human...

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Main Authors: de Vasconcellos, Jaira F., Fasano, Ross M., Lee, Y. Terry, Kaushal, Megha, Byrnes, Colleen, Meier, Emily R., Anderson, Molly, Rabel, Antoinette, Braylan, Raul, Stroncek, David F., Miller, Jeffery L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154803/
https://ncbi.nlm.nih.gov/pubmed/25188417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106924
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