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Revealing Molecular Mechanisms by Integrating High-Dimensional Functional Screens with Protein Interaction Data

Functional genomics screens using multi-parametric assays are powerful approaches for identifying genes involved in particular cellular processes. However, they suffer from problems like noise, and often provide little insight into molecular mechanisms. A bottleneck for addressing these issues is th...

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Autors principals: Simeone, Angela, Marsico, Giovanni, Collinet, Claudio, Galvez, Thierry, Kalaidzidis, Yannis, Zerial, Marino, Beyer, Andreas
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154648/
https://ncbi.nlm.nih.gov/pubmed/25188415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003801
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