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Data-Derived Modeling Characterizes Plasticity of MAPK Signaling in Melanoma
The majority of melanomas have been shown to harbor somatic mutations in the RAS-RAF-MEK-MAPK and PI3K-AKT pathways, which play a major role in regulation of proliferation and survival. The prevalence of these mutations makes these kinase signal transduction pathways an attractive target for cancer...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4154640/ https://ncbi.nlm.nih.gov/pubmed/25188314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003795 |
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