Data-Derived Modeling Characterizes Plasticity of MAPK Signaling in Melanoma

The majority of melanomas have been shown to harbor somatic mutations in the RAS-RAF-MEK-MAPK and PI3K-AKT pathways, which play a major role in regulation of proliferation and survival. The prevalence of these mutations makes these kinase signal transduction pathways an attractive target for cancer...

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Bibliographic Details
Main Authors: Bernardo-Faura, Marti, Massen, Stefan, Falk, Christine S., Brady, Nathan R., Eils, Roland
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154640/
https://ncbi.nlm.nih.gov/pubmed/25188314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003795
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