Activin Type 2 Receptor Restoration in MSI-H Colon Cancer Suppresses Growth and Enhances Migration With Activin

BACKGROUND & AIMS: Colon cancers with high-frequency microsatellite instability (MSI-H) develop frameshift mutations in tumor suppressors as part of their pathogenesis. ACVR2 is mutated at its exon 10 polyadenine tract in >80% of MSI-H colon cancers, coinciding with loss of protein. ACVR2 tra...

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Autores principales: JUNG, BARBARA H., BECK, STAYCE E., CABRAL, JENNIFER, CHAU, EDDY, CABRERA, BETTY L., FIORINO, ANTONIO, SMITH, E. JULIETA, BOCANEGRA, MELANIE, CARETHERS, JOHN M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154562/
https://ncbi.nlm.nih.gov/pubmed/17258738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2006.11.018
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