Blockade of maternal anti-HPA-1a-mediated platelet clearance by an HPA-1a epitope-specific F(ab′)(2) in an in vivo mouse model of alloimmune thrombocytopenia

BACKGROUND: Neonatal alloimmune thrombocytopenia (NAIT) is most commonly caused by transplacental passage of maternal human platelet-specific alloantigen (HPA)-1a antibodies that bind to fetal platelets (PLTs) and mediate their clearance. SZ21, a monoclonal antibody (MoAb) directed against PLT glyco...

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Main Authors: Bakchoul, Tamam, Boylan, Brian, Sachs, Ulrich J. H., Bein, Gregor, Ruan, Changgeng, Santoso, Sentot, Newman, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154534/
https://ncbi.nlm.nih.gov/pubmed/19000229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1537-2995.2008.01972.x
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